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Biodefense Compound Screening

13.2M/sec

Compounds screened per second against any pathogen target. H5N1. Anthrax. Plague. Smallpox. Ebola.
Complete countermeasure portfolios. Field-deployable. Ready before the outbreak.

The Gap

Pandemics move in days.
Drug discovery took years.

COVID-19 killed millions before effective treatments reached patients. The bottleneck was not biology — the virus was sequenced within days. The bottleneck was the time to screen, filter, and validate compounds against the target. 22Rx runs that screen at 13.2 million compounds per second. A complete therapeutic portfolio against a novel pathogen in hours, not years.

13.2M
Compound screens per second
6 min
COVID treatments found (Paxlovid + Remdesivir)
60%
H5N1 case fatality rate — no approved treatment
BARDA Priority Threats

Every tier-1 biodefense threat.
Complete drug portfolios.

Pathogen Current Status 22Rx Approach Mechanism
H5N1 Avian Influenza No approved treatment. Oseltamivir partial. HA-fusion inhibitors Novel — no resistance possible
Anthrax (B. anthracis) Ciprofloxacin + antitoxin LF protease inhibitors Toxin neutralization
Plague (Y. pestis) Streptomycin (resistance risk) Type III secretion blockers Virulence disruption
Smallpox (Variola) Tecovirimat only Viral polymerase inhibitors Replication block
Ebola / Marburg mAbs — IV only, limited supply VP40 matrix protein blockers Budding inhibition
Novel pathogen (day zero) Years Hours Sequence → screen → candidate
Field Deployment

Not just discovery.
Deployable anywhere.

01
Sequence-to-Screen
Pathogen sequence received → target protein modeled → compound library screened. No human intervention required between sequence receipt and hit list delivery.
02
Multi-Pathogen Parallel
Screen against multiple threat organisms simultaneously. One lock-free compute cluster handles concurrent screens without performance degradation.
03
Resistance Prediction
LoNC models mutation escape pathways before treatment begins. Pre-designed second and third-line compounds ready before resistance emerges.
04
Field Hardware
Runs on commodity CPU hardware. No GPU, no specialized equipment. Forward operating base with a standard server can run the full screening pipeline.
Coverage

Every threat class.
Bacteria. Virus. Toxin.

H5N1 / H7N9 pandemic influenza
SARS-CoV-3 (future) pandemic preparedness
Anthrax BARDA Cat A
Plague BARDA Cat A
Smallpox BARDA Cat A
Ebola / Marburg BARDA Cat A
Botulinum toxin weaponizable
VX / Novichok antidotes nerve agents
Drug-resistant TB MDR / XDR
MRSA / CRE hospital superbugs